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05/22/07 11:50 PM ET

Sosa cracks 598th career home run

Slugger hits first career long ball off Twins ace Santana

ARLINGTON -- Sammy Sosa didn't have much of a reaction to hitting his 598th career home run on Tuesday night, even if it did come off two-time Cy Young Award winner Johan Santana.

"When you go up against a guy like Santana, one run is not going to be enough," Sosa said.

One run is all the Rangers got, and Sosa was the one who provided it. Sosa belted a 3-2 fastball into the bleachers in deep center field in the second inning at Rangers Ballpark in Arlington, leaving him two home runs short of 600 for his career.

The home run accounted for the first run of the game, but the Minnesota Twins rallied for a 7-1 victory and that made it difficult for Sosa to savor taking one step closer to history. He is two homers away from being only the fifth player in Major League history to hit 600 career home runs.

The other four are Hank Aaron, Barry Bonds, Babe Ruth and Willie Mays.

"I'm not even thinking about that right now," Sosa said after the game. "I'm just coming here to do my job every day."

The home run traveled 414 feet and was his first career home run off Santana. Sosa walked in his next two plate appearances against Santana before striking out against reliever Pat Neshek in the eighth.

Sosa is hitting .268 with 10 home runs and a club-high 36 RBIs this season. Rangers manager Ron Washington said Sosa will likely get Wednesday off. The Rangers also are off on Thursday before opening a three-game series against the Boston Red Sox on Friday. Daisuke Matsuzaka will pitch for the Red Sox.

T.R. Sullivan is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.