Lewis was scheduled to pitch on Tuesday, but instead will need surgery to repair a torn flexor tendon in his right elbow. Martin Perez will make his third career start after being recalled from Triple-A Round Rock on Monday.
Perez went 1-1 with a 5.54 ERA in four appearances in his first big league stint earlier this year. He won his first Major League start on June 30 against Oakland. He lost his second start on July 6 vs. the Twins before being sent back down when Lewis was activated from the disabled list last week.
"I didn't expect to be back so soon," Perez said. "But they brought me back because they trust me. And if they trust me, I have to fulfill what they expect from me."
The left-hander will look to extend Boston's losing streak to five games. The Red Sox dropped the series opener, 9-1, on Monday to fall below .500 for the first time since June 16, when they were 32-33.
Boston finds itself back in last place in the American League East, but the club is not worried about its recent slump.
"I feel great about this team every day," said first baseman Adrian Gonzalez. "I feel we can go out there and beat anybody that's on the other side of the field."
Clay Buchholz could be the man to get the Red Sox back on track. The right-hander was spectacular in his last start, allowing one run in eight innings against the White Sox on Thursday. Over his last seven outings, Buchholz is 4-1 with a 2.63 ERA and 45 strikeouts in 51 1/3 innings.
Red Sox: Gonzalez recognized with award
Despite Boston's up-and-down week, Gonzalez was named the American League Player of the Week.
The first baseman had 12 hits, three homers and 12 RBIs in seven games as the Sox went 3-4. Gonzalez scored five runs and had 21 total bases.
"It's a good award," said Gonzalez. "It doesn't feel great after getting swept [by the Blue Jays]. If there's any consolation, it will come with winning a series here and then winning a series in New York."
Will Middlebrooks is back in Texas for the first time since taking over as Boston's everyday third baseman in late June.
Middlebrooks was raised in Texarkana and has family and friends in town for the series. He makes his home in the Greater Dallas area during the offseason.
Middlebrooks doubled in his first at-bat on Monday. He finished the game 2-for-4 with a strikeout.
Rangers: Washington keeping faith in Hamilton
Rangers manager Ron Washington knows his club will need Josh Hamilton to be at his best for Texas to make it back to the World Series.
Hamilton entered the series with just six hits in his last 12 games but went 1-for-3 with an RBI double in the third inning on Monday. The outfielder struck out 14 times on the Rangers' recent 10-game road trip that ended Sunday. He struck out once on Monday.
But Washington is certain the All-Star will return to form sooner rather than later.
"He's going to rise to the challenge," Washington said. "This game will humble you. Don't ever think you're better than this game. It will knock you down. He's been challenged. ... That's the beauty of this game. When you're challenged, that's when you figure out what you're made of. It's not when you're doing well. When you're not doing well, that's when you find out the character and makeup of someone. Josh will show us what he's all about."
Elvis Andrus extended his hitting-streak to 11 games with an infield single in the third inning on Monday night. Andrus went 1-for-4 with an RBI. He is the fifth Rangers player this season to have a hit streak of at least 10 games.
The Red Sox are 2-5 without slugger David Ortiz, who has not played since Monday and is on the 15-day DL with a strained right Achilles.
Rangers catcher Mike Napoli is 4-for-11 (.364) in his career against Buchholz with one home run.